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SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity

N Fang1, G A Koretzky

  • 1Graduate Program in Immunology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.

The Journal of Biological Chemistry
|May 29, 1999
PubMed
Summary

Signaling lymphocytic phosphoprotein (SLP-76) and Vav proteins are crucial for T cell activation. While their interaction is not essential for synergistic interleukin-2 (IL-2) promoter activity, they function in distinct pathways regulating T cell gene expression.

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