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Updated: Sep 13, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Stenting for atherosclerotic occlusive disease of the subclavian artery
J A Rodriguez-Lopez1, A Werner, R Martinez
1Department of Cardiovascular and Endovascular Surgery, Arizona Heart Institute, Phoenix 85006, USA.
Insights
Subclavian artery stenting is a safe and effective treatment for stenosis and occlusion, improving symptoms like vertebrobasilar insufficiency and upper limb ischemia. While short- and mid-term results are promising, long-term durability requires further investigation.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Medical Devices
Background:
- Subclavian artery disease, including stenosis and occlusion, can lead to significant symptoms such as vertebrobasilar insufficiency and upper limb ischemia.
- Traditional treatments like balloon angioplasty alone have shown limitations in efficacy and durability.
- Stenting offers a potential solution to improve outcomes in these challenging vascular lesions.
Purpose of the Study:
- To evaluate the safety and efficacy of subclavian artery stenting for treating atherosclerotic lesions.
- To assess the outcomes of stenting in patients with various indications, including vertebrobasilar insufficiency and upper limb ischemia.
- To compare the results of stenting with previous reports of balloon angioplasty alone.
Main Methods:
- A retrospective study involving 69 patients (70 subclavian arteries) treated between July 1991 and December 1995.
- Patients underwent intraluminal balloon dilatation followed by stent implantation for primary atherosclerotic stenoses (>70%) or total occlusions.
- Indications included vertebrobasilar insufficiency, upper limb ischemia, subclavian steal phenomenon, and protection of vascular access or bypass grafts.
Main Results:
- Stenting was performed for stenosis in 78% of cases and for total occlusion in 22%.
- Successful treatment was observed for various indications, with significant improvements in symptoms.
- Short- and mid-term patency rates were good, demonstrating the feasibility and safety of the procedure.
Conclusions:
- Subclavian artery stenting is a safe and feasible option for treating atherosclerotic stenosis and occlusion.
- The procedure offers improved short- and mid-term patency compared to balloon angioplasty alone.
- Long-term durability of subclavian artery stenting remains to be determined through further follow-up studies.
Abstract:
The purpose of this study was to evaluate the results of stenting subclavian artery pathologic lesions. Between July 1991 and December 1995, 69 patients (36 males: mean age 67 years, range 34-87 years) underwent intraluminal balloon dilatations followed by stent implantations in 70 subclavian arteries to treat primary atherosclerotic stenoses > 70%. Twenty-three patients (34%) were treated for vertebrobasilar insufficiency (VBI), 25 patients (36%) were treated for upper limb ischemia (ULI), and 10 patients (15%) were treated for both VBI and ULI. Other indications included symptomatic subclavian steal phenomenon (SSS), protection of dialysis arteriovenous fistula, coronary steal syndrome, protection of axilloaxillary bypass, distal embolization, and protection of left internal mammary artery (LIMA)-coronary bypass. Fifty-three cases (78%) were treated for stenosis and 17 cases (22%) for total occlusion of the origin of the subclavian artery. The results of this series indicate that stenting of subclavian artery stenosis appears safe and feasible with good short and mid-term patency, improving at those intervals the initial disappointing reports of balloon angioplasty alone. However, its long-term durability is at present unknown.
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