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Updated: Aug 6, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Acute myeloblastic leukemia (M0) with an unusual chromosomal abnormality: translocation (1;14)(p13;q32)
C Tecimer1, B A Loy, A W Martin
1Department of Hematology/Medical Oncology, University of Louisville School of Medicine, Kentucky, USA.
Abstract:
We describe a case of acute myeloblastic leukemia, French-American-British subclassification of M0 (AML-M0), with an unusual chromosomal abnormality. The diagnosis of AML-M0 was made morphologically, cytochemically, and immunophenotypically. At the time of diagnosis, cytogenetic studies were performed, revealing a translocation involving chromosomes 1 and 14--specifically t(1;14)(p13;q32). The patient responded to high-dose ARA-C. In our survey of the literature, we were unable to find a reported case of AML-M0 with this chromosomal translocation.
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