Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Liposomes as a gene delivery system.

C Ropert1

  • 1Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte, MG, Brasil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|May 29, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of Toll-like receptors 2 and 4 on reactive oxygen species and nitric oxide production by macrophage cells stimulated with root canal pathogens.

Oral microbiology and immunology·2008
Same author

Cell surface fluctuations studied with defocusing microscopy.

Physical review. E, Statistical, nonlinear, and soft matter physics·2003
Same author

A mitogenic signal triggered at an early stage of vaccinia virus infection: implication of MEK/ERK and protein kinase A in virus multiplication.

The Journal of biological chemistry·2001
Same author

Requirement of mitogen-activated protein kinases and I kappa B phosphorylation for induction of proinflammatory cytokines synthesis by macrophages indicates functional similarity of receptors triggered by glycosylphosphatidylinositol anchors from parasitic protozoa and bacterial lipopolysaccharide.

Journal of immunology (Baltimore, Md. : 1950)·2001
Same author

Signaling of immune system cells by glycosylphosphatidylinositol (GPI) anchor and related structures derived from parasitic protozoa.

Current opinion in microbiology·2000
Same author

In-vivo treatment with benznidazole enhances phagocytosis, parasite destruction and cytokine release by macrophages during infection with a drug-susceptible but not with a derived drug-resistant Trypansoma cruzi population.

Parasite immunology·1999
Same journal

RETRACTION: NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt/β-catenin signaling pathway.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

RETRACTION: Differential expression of microRNA-411 and 376c is associated with hypertension in pregnancy.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

RETRACTION: Comparison of two treatments for dry eye disease after corneal refractive surgery.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

The emerging role of the microbiome in bladder cancer: prognostic implications and treatment response.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

Standardizing the lateral fluid percussion model of trauma in marmosets (Callithrix jacchus): regional vulnerability and inflammatory response.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

COVID-19 mortality risk among women with ovarian cancer: a matched case-control study.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
See all related articles

Gene therapy utilizes advanced vectors for safe and efficient DNA delivery. Liposome and cationic lipid technologies are key innovations in nonviral gene transfer for clinical applications.

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Genetics

Background:

  • Gene therapy is a rapidly advancing field with significant clinical trial progress.
  • Effective gene delivery vectors are crucial for successful gene therapy strategies.
  • Nonviral DNA-mediated gene transfer methods, like liposomes, are actively developed.

Purpose of the Study:

  • To review the development and application of nonviral gene delivery systems.
  • To highlight the importance of vector design for safety and efficiency in gene therapy.
  • To discuss advancements in liposome and cationic lipid-based gene transfer technologies.

Main Methods:

  • Review of existing literature on gene therapy vectors.
  • Analysis of liposome-based DNA delivery systems.

Related Experiment Videos

  • Evaluation of cationic lipid technologies for gene transfer.

    • Main Results:

    • Liposome-based systems incorporate targeting and lysosomal escape mechanisms.
    • Cationic lipid technology has emerged as a promising approach for gene transfer.
    • Significant interest exists in these nonviral methods for gene delivery.

    Conclusions:

    • Nonviral vectors, particularly liposomes and cationic lipids, are vital for advancing gene therapy.
    • Continued innovation in vector design is essential for overcoming gene delivery challenges.
    • These technologies show great potential for future clinical applications in gene therapy.