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Multiple sclerosis: diagnostic usefulness of cerebrospinal fluid
Annals of Neurology
|November 1, 1977
Summary
Diagnosing multiple sclerosis (MS) is easier with new cerebrospinal fluid (CSF) tests. These assays detect abnormalities in over 90% of definite MS cases, aiding diagnosis and research.
Area of Science:
- Neurology
- Clinical Diagnostics
- Biochemistry
Background:
- Diagnosing early, atypical, or progressive multiple sclerosis (MS) presents significant clinical challenges.
- Historically, assays for common cerebrospinal fluid (CSF) abnormalities were not readily available in clinical settings.
Purpose of the Study:
- To highlight the diagnostic utility of newly available cerebrospinal fluid (CSF) assays in multiple sclerosis (MS).
- To discuss common CSF protein abnormalities and their role in MS diagnosis and pathogenesis research.
Main Methods:
- Utilized standardized, clinically available assays for cerebrospinal fluid (CSF) protein analysis.
- Focused on quantifying immunoglobulin G (IgG) percentage, IgG/albumin index, and detecting oligoclonal IgG bands.
Main Results:
- Cerebrospinal fluid (CSF) abnormalities were identified in over 90% of clinically definite multiple sclerosis (MS) cases using newer techniques.
- Key abnormalities include elevated IgG, elevated IgG/albumin index, and presence of oligoclonal IgG bands.
Conclusions:
- Standardized CSF protein analysis significantly aids in the diagnosis of multiple sclerosis (MS).
- These CSF markers provide valuable insights into the underlying cause and pathogenesis of MS.