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Related Experiment Videos

Local cerebral glucose utilization in the normal conscious macaque monkey.

C Kennedy, O Sakurada, M Shinohara

    Annals of Neurology
    |October 1, 1978
    PubMed
    Summary

    The [14C]deoxyglucose method accurately measures brain glucose use in macaque monkeys. This study established key constants and revealed distinct glucose utilization patterns in gray and white matter.

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    Area of Science:

    • Neuroscience
    • Physiology

    Background:

    • The [14C]deoxyglucose method is a key technique for measuring local cerebral glucose utilization.
    • Previous studies have primarily utilized this method in rodents.

    Purpose of the Study:

    • To adapt and validate the [14C]deoxyglucose method for quantitative analysis of local cerebral glucose utilization in macaque monkeys.
    • To determine the regional distribution and heterogeneity of glucose metabolism in the macaque brain.

    Main Methods:

    • Evaluation of essential constants, including the lumped constant and rate constants, for the operational equation of the [14C]deoxyglucose method in conscious macaque monkeys.
    • Application of the validated method to measure local cerebral glucose utilization across different brain regions.

    Main Results:

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    • The lumped constant was determined to be 0.344 (SEM, +/- 0.036) in normal conscious monkeys.
    • Local cerebral glucose utilization varied significantly, with higher rates in gray matter and lower rates in white matter.
    • Heterogeneity in glucose utilization was observed, with patterns sometimes correlating with known cytoarchitecture or electrophysiological findings, and notably showing columnar distributions in the cerebral cortex.

    Conclusions:

    • The [14C]deoxyglucose method is applicable to macaque monkeys, providing valuable data on brain energy metabolism.
    • The findings highlight significant regional differences and functional organization reflected in glucose utilization patterns within the macaque brain.
    • Observed columnar patterns in the cerebral cortex may represent a metabolic correlate of functional columnar organization.