[Intracranial collision tumor--A case report (author's transl)]

Area of Science:

• Neuro-oncology
• Pathology
• Radiation Oncology

Background:

• Chordomas are rare, slow-growing bone tumors originating from notochordal remnants.
• Hemangioblastomas are typically benign vascular tumors, often associated with Von Hippel-Lindau disease.
• Collision tumors, where two distinct neoplasms coexist, are infrequently reported in the central nervous system.

Observation:

• A 21-year-old male presented with a nasopharyngeal chordoma treated with surgery and Co60 irradiation.
• A subsequent severe double vision led to the discovery of a coexisting intracranial hemangioblastoma.
• Histological examination confirmed the intimate juxtaposition of chordoma and hemangioblastoma.

Findings:

• The patient underwent multiple surgeries and additional Co60 irradiation for tumor progression.
• Meningitis developed, indicating tumor extension into the meninges.
• The final diagnosis post-mortem was hemangioblastoma, with the initial chordoma showing no malignant features.

Implications:

• This case presents a unique instance of intracranial chordoma and hemangioblastoma collision.
• The authors hypothesize that post-operative radiation therapy may have induced the hemangioblastoma.
• This raises concerns about potential radiation-induced secondary neoplasms in patients treated for primary brain tumors.