Effect of angiotensin on the central action of dopamine

Angiotensin given intraventricularly enhances amphetamine but not apomorphine-induced stereotypy 30 min. after peptide administration. Simultaneous injection of angiotensin and dopamine increases amphetamine -- while decreases apomorphine -- induced stereotypy. The stereotypy produced either by apomorphine or amphetamine in rats pretreated with Ro 4-4602 + L-DOPA was diminished by angiotensin. Angiotensin elevated haloperidol-induced catalepsy. A possibility that angiotensin may inhibit both release and uptake of dopamine by nerve endings is discussed.