Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pax 4 and 6 regulate gastrointestinal endocrine cell development.

L I Larsson1, L St-Onge, D M Hougaard

  • 1Department of Molecular Cell Biology, Statens Serum Institut, Copenhagen, Denmark. Larsson@biobase.dk

Mechanisms of Development
|June 1, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The iPSYCH2012 case-cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders.

Molecular psychiatry·2017
Same author

Testosterone therapy preserves muscle strength and power in aging men with type 2 diabetes-a randomized controlled trial.

Andrology·2017
Same author

Differential DNA methylation at birth associated with mental disorder in individuals with 22q11.2 deletion syndrome.

Translational psychiatry·2017
Same author

The role of genetic liability in the association of urbanicity at birth and during upbringing with schizophrenia in Denmark.

Psychological medicine·2017
Same author

COMT Val158Met and MTHFR C677T moderate risk of schizophrenia in response to childhood adversity.

Acta psychiatrica Scandinavica·2017
Same author

MR spectroscopy of hepatic fat and adiponectin and leptin levels during testosterone therapy in type 2 diabetes: a randomized, double-blinded, placebo-controlled trial.

European journal of endocrinology·2017

The Pax 4 and Pax 6 genes are crucial for the development of hormone-secreting cells in the gut and pancreas. Their deletion significantly impacts the expression of key gastrointestinal and pancreatic hormones.

Area of Science:

  • Endocrinology
  • Developmental Biology
  • Gastroenterology

Background:

  • The precise mechanisms governing the cell-specific and compartmentalized expression of gut and pancreatic hormones remain largely unelucidated.
  • Understanding these mechanisms is vital for comprehending gastrointestinal and pancreatic endocrine function.

Purpose of the Study:

  • To investigate the roles of Pax 4 and Pax 6 genes in the differentiation of gastrointestinal and pancreatic endocrine cells.
  • To identify common regulatory pathways for endocrine cell development across the pancreas and proximal gastrointestinal tract.

Main Methods:

  • Gene deletion studies involving Pax 4 and Pax 6.
  • Analysis of hormone-secreting cell populations in the duodenum, jejunum, and distal stomach.

Related Experiment Videos

Main Results:

  • Deletion of Pax 4 gene resulted in the near-complete absence of duodenal and jejunal hormone-secreting cells, along with serotonin and somatostatin cells in the distal stomach.
  • Deletion of Pax 6 gene led to the elimination of duodenal GIP cells and gastrin and somatostatin cells in the distal stomach.

Conclusions:

  • Pax 4 and Pax 6 genes collectively regulate the differentiation of all proximal gastrointestinal endocrine cells.
  • These findings suggest shared developmental pathways for pancreatic and gastrointestinal endocrine cell differentiation.