Preparation of biodegradable microparticles using solution-enhanced dispersion by supercritical fluids (SEDS)

Area of Science:

• Polymer science
• Materials science
• Chemical engineering

Background:

• Microparticle production is crucial for various applications, including drug delivery and tissue engineering.
• Traditional methods often involve toxic organic solvents, posing environmental and health concerns.
• Developing greener and more efficient microparticle fabrication techniques is an ongoing research priority.

Purpose of the Study:

• To evaluate the Solution-Enhanced Dispersion by Supercritical Fluids (SEDS) process for producing polymeric microparticles.
• To assess the feasibility of using biodegradable polymers with the SEDS technique.
• To investigate the reduction of toxic solvent usage in microparticle manufacturing.

Main Methods:

• Biodegradable polymers including Poly (DL-lactide-co-glycolide) (DL-PLG), Poly (L-lactide) (L-PLA), Poly (DL-lactide) (DL-PLA), and Polycaprolactone (PCL) were utilized.
• Polymer solutions in organic solvents were dispersed and sprayed with supercritical CO2.
• Extraction of organic solvents led to the formation of solid microparticles, with reduced use of dichloromethane (MC).

Main Results:

• Microparticles were successfully produced from all tested polymers.
• Particle size and morphology varied depending on the polymer type and solvent choice.
• Discrete spherical DL-PLG microparticles (130 microm) were obtained; L-PLA microparticles ranged from 0.5-5 microm; PCL microparticles measured 30-210 microm, with film formation observed at high pressure.

Conclusions:

• The SEDS process is a promising method for manufacturing microparticles from biodegradable polymers.
• This technique offers an alternative to traditional methods, significantly reducing the need for hazardous solvents.
• SEDS demonstrates potential for environmentally friendly and efficient microparticle production.