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Updated: Aug 31, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
Published on: December 27, 2016
What is apoptosis and what is its relevance to vascular biology?
1Université de Montréal, Montréal, Canada. hamet@ere.umontreal.ca
Abstract:
To maintain vascular mass and structure, an intricate balance must be maintained between apoptosis (programmed cell death) and cell proliferation. Apoptosis is thought to be regulated by a complex cascade of specific protease activations. Increased rates of apoptosis, which occur during limited time windows, have been implicated in animal models of hypertension and cardiac hypertrophy. In these models, apoptosis was effectively upregulated by three of the four antihypertensive agents studied. Work to identify the gene that controls apoptosis is ongoing.
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