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Premature menopause after cancer treatment
E Muscari Lin1, J L Aikin, B C Good
1University of Virginia Cancer Center, Charlottesville, USA.
Purpose:
The purpose of this report is to examine the impact that cancer therapies have on ovarian function.
Overview:
Symptoms of and conditions due to estrogen deficiency after cancer therapy are described, and interventions are proposed. The consequences of short-term as well as prolonged estrogen deficiency-including vasomotor instability, infertility, genitourinary atrophy, coronary artery disease, and osteoporosis-are discussed.
Clinical Implications:
Symptoms and conditions associated with premature menopause may cause additional stress for women who undergo cancer therapy. Knowledge about what happens to these women can enable healthcare providers to help them make decisions about cancer treatment, engage in self-care activities, and explore options for preserving fertility.