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Related Experiment Videos

Discoidin domain receptors: structural relations and functional implications.

W Vogel1

  • 1Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada. vogel@mshri.on.ca

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|June 3, 1999
PubMed
Summary

Discoidin domain receptors (DDRs) are cell surface receptors activated by collagen. These receptor tyrosine kinases play a role in cell communication and tissue organization, with implications for clinical research.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Multicellular organisms utilize extracellular matrix (ECM) for structural support and cell communication.
  • Cell surface receptors, including receptor tyrosine kinases (RTKs), mediate signaling in response to ECM components and soluble ligands.
  • Discoidin domain receptors (DDRs) are a distinct subgroup of RTKs characterized by a discoidin homology repeat.

Purpose of the Study:

  • To review the function of discoidin domain receptors (DDRs) in cellular signaling.
  • To discuss the identification of collagen as ligands for DDR1 and DDR2.
  • To explore the downstream signaling pathways and clinical relevance of DDRs.

Main Methods:

  • Bioinformatic analysis of DDR sequences across different species.

Related Experiment Videos

  • Biochemical assays to identify collagen as ligands for DDR1 and DDR2.
  • Phosphorylation studies to investigate DDR activation and downstream signaling.

    • Main Results:

    • Collagen binding to DDR1 and DDR2 triggers delayed but sustained tyrosine kinase activation.
    • DDRs possess multiple tyrosine phosphorylation sites for relaying intracellular signals.
    • Non-mammalian orthologs of DDRs have been identified, suggesting conserved functions.

    Conclusions:

    • DDRs are crucial mediators of collagen-induced signaling pathways.
    • Understanding DDR function is important for exploring their role in tissue homeostasis and disease.
    • Further research into DDR cross-talk and clinical applications is warranted.