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Updated: Jul 29, 2026
11:32
Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
Published on: March 27, 2020
TRANSCRIPTION FACTORS AND CANCER. THE EXAMPLE OF PAX GENES.
1Dipartimento di Scienze e Tecnologie Biomediche, University of Udine, Udine, 33100, Italy.
Advances in Clinical Pathology : the Official Journal of Adriatic Society of Pathology
|June 3, 1999
Summary
Pax genes, crucial for development, are implicated in human cancers. Understanding their oncogenic potential and target genes is key to unraveling neoplastic disease mechanisms.
Area of Science:
- Molecular Biology
- Developmental Biology
- Oncology
Background:
- Pax genes encode transcription factors vital for cell differentiation and embryonic development, conserved across vertebrates.
- These genes are characterized by a paired box domain enabling sequence-specific DNA recognition.
- Mutations in Pax genes lead to abnormal phenotypes, and recent studies highlight their role in human tumors.
Purpose of the Study:
- To review the relevance of Pax genes in human cancer.
- To identify target genes mediating the biological effects of Pax proteins in cancer.
- To understand the molecular basis of neoplastic diseases linked to Pax gene alterations.
Main Methods:
- Review of existing literature on Pax genes, their functions, and their role in cancer.
- Analysis of in vitro and in vivo assays demonstrating oncogenic potential.
- Focus on identifying target genes regulated by Pax proteins.
Main Results:
- Pax genes possess oncogenic potential, demonstrated by in vitro and in vivo assays.
- Misexpression or structural alterations of Pax genes are detected in various human tumors.
- Pax proteins exhibit critical biochemical and biological properties relevant to cancer.
Conclusions:
- Pax genes play a significant role in human cancer development.
- Identifying Pax target genes is crucial for understanding the molecular basis of cancer.
- Further research into Pax gene functions can impact cancer diagnostics and therapeutics.
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