Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mechanisms of antigen presentation.

P E Jensen1

  • 1The Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA. pjensen@bimcore.emory.edu

Clinical Chemistry and Laboratory Medicine
|June 3, 1999
PubMed
Summary

T-lymphocytes use major histocompatibility complex (MHC) molecules to recognize foreign peptides. Viruses can evade immune detection by interfering with the antigen processing pathways that generate these peptide-MHC complexes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trade-off between resistance and persistence in high cell density cultures.

mSystems·2025
Same author

Thermal unfolding and refolding of a lytic polysaccharide monooxygenase from <i>Thermoascus aurantiacus</i>.

RSC advances·2022
Same author

Water-soluble chlorophyll-binding proteins from Brassica oleracea allow for stable photobiocatalytic oxidation of cellulose by a lytic polysaccharide monooxygenase.

Biotechnology for biofuels·2020
Same author

Expression and secretion of a lytic polysaccharide monooxygenase by a fast-growing cyanobacterium.

Biotechnology for biofuels·2019
Same author

Light-driven oxidation of polysaccharides by photosynthetic pigments and a metalloenzyme.

Nature communications·2016
Same author

Heat-washout measurements compared to distal blood pressure and perfusion in orthopaedic patients with foot ulcers.

Clinical physiology and functional imaging·2015

Area of Science:

  • Immunology
  • Molecular Biology
  • Virology

Background:

  • T-lymphocytes identify peptide antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs).
  • Two primary pathways generate peptide-MHC complexes: MHC class II for endosomal proteins and MHC class I for cellular proteins.

Purpose of the Study:

  • To elucidate the mechanisms of antigen processing and presentation by MHC molecules.
  • To understand the roles of accessory proteins in immune response specificity.
  • To investigate viral strategies for evading immune recognition by subverting antigen processing.

Main Methods:

  • Analysis of MHC class I and class II antigen processing pathways.
  • Investigation of accessory protein functions in peptide generation and loading.
  • Examination of viral mechanisms to inhibit antigen processing.

Main Results:

  • MHC class II pathway samples endosomal proteins for CD4+ T-cell recognition.
  • MHC class I pathway presents cellular peptides for CD8+ T-cell surveillance.
  • Accessory proteins modulate antigen presentation efficiency and specificity.
  • Viruses have evolved to disrupt antigen processing for immune evasion.

Conclusions:

  • Antigen processing and presentation are critical for adaptive immunity.
  • Viral subversion of these pathways represents a significant immune evasion strategy.

Related Experiment Videos