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Regulation of leukocyte trafficking by lipoxins
P Diamond1, A McGinty, D Sugrue
1Department of Medicine and Therapeutics, Centre for Vascular Inflammation and Vascular Research, University College Dublin, Mater Misericordiae Hospital, Ireland.
Clinical Chemistry and Laboratory Medicine
|June 3, 1999
Abstract:
Lipoxins are lipoxygenase interaction products formed by transcellular metabolism during host defence and inflammation. In model systems, lipoxins modulate polymorphonuclear leukocytes (PMN) chemotaxis, adhesion molecule expression, inhibit PMN-endothelial cell adhesion, and attenuate cytokine release from epithelial cells. These observations raise the possibility that lipoxins are 'stop signals' for PMN-mediated tissue injury and promote the resolution of acute inflammation.