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Related Experiment Videos

PDMS-based polyurethanes with MPEG grafts: synthesis, characterization and platelet adhesion study.

J H Park1, K D Park, Y H Bae

  • 1Center for Biomaterials and Biotechnology, Department of Materials Science and Engineering, Kwangju Institute of Science and Technology, South Korea.

Biomaterials
|June 3, 1999
PubMed
Summary

New polyurethane (PU) biomaterials coated PDMS devices, reducing platelet adhesion. Grafting monomethoxy poly(ethylene glycol) (MPEG) onto poly(dimethyl siloxane) (PDMS)-based PU significantly enhanced hemocompatibility, making them ideal for biomedical applications.

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Polymer Chemistry

Background:

  • Poly(dimethyl siloxane) (PDMS) is widely used in biomedical devices.
  • PDMS-based materials can cause adverse biological responses, such as platelet adhesion.
  • Developing advanced polymeric biomaterials is crucial for improving device performance and patient safety.

Purpose of the Study:

  • To synthesize novel polyurethane (PU) biomaterials for coating PDMS-based biomedical devices.
  • To investigate the effect of monomethoxy poly(ethylene glycol) (MPEG) grafting on the properties and hemocompatibility of PDMS-based PUs.
  • To evaluate the potential of these new materials as improved coatings for biomedical applications.

Main Methods:

  • Synthesis of PDMS-based PUs using ethylene glycol (EG) or diethyl bis(hydroxymethyl) malonate (DBM) as chain extenders.

Related Experiment Videos

  • Grafting of MPEG onto PDMS-based PUs via allophanate and esterification reactions.
  • Characterization of molecular structures using FT-IR and 1H-NMR.
  • Morphological analysis using dynamic mechanical analysis (DMA) and differential scanning calorimetry (DSC).
  • Evaluation of platelet adhesion on polymer surfaces.

    • Main Results:

    • The synthesized PDMS-based PUs exhibited increased hydrophobicity compared to Pellethane, attributed to a PDMS-rich surface phase.
    • MPEG grafting significantly increased the hydrophilicity of the PDMS-based PUs.
    • Phase separation in the PUs increased with hard segment content, with MPEG showing compatibility with MDI/DBM hard segments but incompatibility with MDI/EG hard segments.
    • Platelet adhesion was significantly reduced on PDMS-based PUs compared to Pellethane.
    • PDMS-based PUs with MPEG grafts demonstrated the least platelet adhesion, especially those with few hard segments and a distinct PEG phase.

    Conclusions:

    • Novel PDMS-based PUs with grafted MPEG were successfully synthesized as advanced biomaterials.
    • The incorporation of MPEG enhanced hydrophilicity and significantly reduced platelet adhesion, improving hemocompatibility.
    • These MPEG-grafted PDMS-based PUs show great promise for coating biomedical devices, offering superior biocompatibility compared to conventional materials like Pellethane.