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Review: infectious diseases and coagulation disorders
E C van Gorp1, C Suharti, H ten Cate
1Slotervaart Hospital, Department of Internal Medicine/Infectious Diseases, 1066 EC Amsterdam, The Netherlands. Igego@slv.nl
The Journal of Infectious Diseases
|June 3, 1999
Summary
Infections can trigger blood clotting disorders, leading to severe complications like disseminated intravascular coagulation and organ failure. This review explores the link between infections and coagulation, discussing current data and future therapies.
Area of Science:
- Infectious Diseases
- Hematology
- Critical Care Medicine
Background:
- Infections, encompassing bacterial and nonbacterial types, are frequently linked to coagulation system abnormalities.
- These abnormalities can progress to severe conditions such as disseminated intravascular coagulation (DIC) and multiorgan failure.
- Recent decades have seen significant advancements in understanding the pathogenetic mechanisms and the role of cytokines in infection-induced coagulation disorders.
Purpose of the Study:
- To review current data on the intricate association between infectious diseases and the coagulation system.
- To provide insights into the pathogenetic mechanisms and the role of cytokines in these processes.
- To discuss novel therapeutic strategies for managing infection-related coagulation disorders.
Main Methods:
- Comprehensive literature review of in vivo and in vitro studies.
- Analysis of current data on the interplay between infection and coagulation.
- Identification and discussion of emerging therapeutic interventions.
Main Results:
- Infections are a significant trigger for coagulation disorders, including DIC and multiorgan failure.
- Cytokines play a crucial role in the pathogenetic mechanisms linking infection and coagulation.
- A growing body of research elucidates the complex interactions within this pathophysiology.
Conclusions:
- Understanding the relationship between infection and coagulation is critical for physicians managing diverse infections.
- Novel therapeutic strategies are emerging, offering hope beyond supportive care for certain infectious disorders.
- Further research is warranted to fully elucidate and manage these complex clinical scenarios.