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Paronychia associated with antiretroviral therapy
A Tosti1, B M Piraccini, A D'Antuono
1Department of Dermatology, University of Bologna, Via Massarenti 1, I-40138 Bologna, Italy. tosti@almadns.unibo.it
The British Journal of Dermatology
|June 3, 1999
Summary
Painful nail inflammation, known as paronychia, can occur in patients with HIV taking antiretroviral drugs like indinavir and lamivudine. Dermatologists should recognize this side effect to avoid unnecessary invasive treatments.
Area of Science:
- HIV/AIDS Medicine
- Dermatology
- Pharmacology
Background:
- HIV patients often require antiretroviral therapy.
- Adverse drug reactions can impact patient adherence and outcomes.
- Periungual inflammation is a known dermatological condition.
Purpose of the Study:
- To report a series of HIV patients experiencing painful periungual inflammation.
- To highlight a potential side effect of specific antiretroviral drugs.
- To increase dermatologist awareness of this condition.
Main Methods:
- Observational case series.
- Clinical observation of six HIV patients.
- Review of patient treatment regimens.
Main Results:
- Six HIV patients developed painful periungual inflammation affecting multiple nails.
- Lesions appeared 2-12 months after initiating indinavir and lamivudine treatment.
- This condition, paronychia, has been previously associated with indinavir or lamivudine monotherapy.
Conclusions:
- Painful periungual inflammation is a potential side effect of indinavir and lamivudine in HIV patients.
- Dermatologists should consider this adverse drug reaction in HIV patients presenting with nail lesions.
- Awareness can prevent unnecessary invasive procedures for paronychia.