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Related Experiment Videos

Rhinoscleroma: a scanning electron-microscopic study.

H Gaafar, Y Harada

    ORL; Journal for Oto-Rhino-Laryngology and Its Related Specialties
    |January 1, 1976
    PubMed
    Summary
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    Scanning electron microscopy revealed numerous Klebsiella rhinoscleromatis bacilli on nasal epithelial surfaces in rhinoscleroma patients. Mikulicz cells, containing bacilli, were observed migrating from the submucosa, with potential fungal structures also noted.

    Area of Science:

    • Microbiology
    • Pathology
    • Electron Microscopy

    Background:

    • Rhinoscleroma is a chronic granulomatous disease affecting the upper respiratory tract.
    • The causative agent, Klebsiella rhinoscleromatis, is a Gram-negative bacterium.
    • Understanding the ultrastructural pathology is crucial for diagnosing and managing rhinoscleroma.

    Purpose of the Study:

    • To investigate the ultrastructural morphology of Klebsiella rhinoscleromatis within nasal biopsies using scanning electron microscopy.
    • To characterize the interaction between the bacteria and host cells, particularly Mikulicz cells.
    • To identify any other potential microorganisms associated with the disease.

    Main Methods:

    • Nasal biopsies were obtained from six patients diagnosed with rhinoscleroma.

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  • Scanning electron microscopy (SEM) was employed to examine the surface topography and bacterial presence.
  • High-resolution imaging was used to visualize bacilli, host cells, and other structures.

    • Main Results:

    • Numerous Klebsiella rhinoscleromatis bacilli were observed on the epithelial surface of all patients.
    • Bacilli were also found on and within large Mikulicz cells migrating from the tunica propria.
    • Unidentified round bodies and tubular structures, possibly fungal, were noted on the epithelium in four patients.

    Conclusions:

    • Scanning electron microscopy provides detailed insights into the bacterial colonization and host cell interactions in rhinoscleroma.
    • The presence and migration of Mikulicz cells containing bacilli highlight their role in the disease pathogenesis.
    • Further research is needed to elucidate the nature and role of the suspected fungal elements in rhinoscleroma.