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Updated: Oct 2, 2026

Chromatin Immunoprecipitation (ChIP) using Drosophila tissue
Published on: March 23, 2012
The genotype and epigenotype synergize to diversify the spatial pattern of expression of the imprinted H19 gene
1Department of Animal Development and Genetics, Uppsala University, Norbyvagen 18A, S-752 36, Uppsala, Sweden.
Abstract:
Little is known of how the genetic background effects the phenomenon of genomic imprinting. The H19 gene belongs to a cluster of imprinted genes on human chromosome 11. Here we show that the alternative splicing of a human H19 transcript is genotype-specific. Moreover, this variant transcript, which lacks exon 4, is either not found at all, is widely expressed or is confined to extra-villous cytotrophoblasts in first trimester placenta, depending on a combination of the genotype and the sex of the transmitting parent.
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