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The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication
C M Smith1, E Radzio-Andzelm, Madhusudan
1San Diego Supercomputer Center, University of California, La Jolla 92093-0505, USA. csmith@sdsc.edu
Progress in Biophysics and Molecular Biology
|June 4, 1999
Abstract:
The protein kinase catalytic core in essence comprises an extended network of interactions that link distal parts of the molecule to the active site where they facilitate phosphoryl transfer from ATP to protein substrate. This review defines key sequence and structural elements, describes what is currently known about the molecular interactions, and how they are involved in catalysis.