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Ameliorative effect of an urinary preparation on acetaminophen and D-galactosamine induced hepatotoxicity in rats
1Graduate Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan.
Abstract:
The effect of oral administration of a preparation of human urine (PHU) on acute liver injury was examined in rats intoxicated with acetaminophen and D-galactosamine. The results indicated that PHU protected the liver from acetaminophen and D-galactosamine-induced injury as judged by morphological and biochemical observation. An increase in lipid peroxide concentrations and decrease in protein concentrations occurred in the liver by D-galactosamine injection, PHU administration significantly prevented these changes.
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