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[Polysaccharide biological activity dependent on structural characteristics].

O A Aksenov, A N Dranishnikov, N P Elinov

Antibiotiki

|November 1, 1976

Summary

This study investigated Aureobasidium pollulans glucans for anti-influenza properties. Polysaccharide structure, specifically branching and beta-C1-C3 bonds, influenced interferon production and antiviral activity in mice.

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Area of Science:

Mycology
Immunology
Biochemistry

Context:

Extracellular polysaccharides (glucans) from Aureobasidium pollulans exhibit biological activities.
Understanding the structure-activity relationship of these polysaccharides is crucial for their therapeutic potential.

Purpose:

To investigate the anti-influenza and interferonogenic activity of Aureobasidium pollulans-derived glucans.
To determine the correlation between polysaccharide structure (branching, specific glycosidic bonds) and induced interferon levels and anti-influenza efficacy in vivo.

Summary:

Polysaccharides from Aureobasidium pollulans were tested in albino mice.
Early and 24-hour interferon production correlated with specific structural features: branching and beta-C1-C3 bonds for early interferon, and beta-C1-C4 bonds for later interferon.

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Anti-influenza activity was directly dependent on the level of induced interferon, with optimal activity seen in preparations inducing both early and late interferon.

Impact:

Identifies key structural determinants of glucan immunomodulatory and antiviral effects.
Provides insights into developing novel anti-influenza agents from fungal polysaccharides.
Highlights the potential of Aureobasidium pollulans as a source for bioactive compounds.