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[Murine model for experimental studies on attenuated mutants of a Pasteurella multocida strain with pathogenicity for

K Linde, H P Keller

    Archiv Fur Experimentelle Veterinarmedizin
    |January 1, 1976
    PubMed
    Summary

    Researchers developed stable Pasteurella multocida mutants for calf immunization. Live, attenuated Pasteurella multocida germs showed higher immunogenicity than inactivated antigens in mice.

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    Area of Science:

    • Veterinary Microbiology
    • Bacteriology
    • Immunology

    Context:

    • Investigating Pasteurella multocida pathogenicity in calves.
    • Developing novel immunization strategies for livestock.

    Purpose:

    • To isolate and characterize stable Pasteurella multocida mutants.
    • To evaluate the immunogenicity of attenuated Pasteurella multocida in a mouse model.

    Summary:

    • Stable Sm-d mutants of Pasteurella multocida were successfully isolated and their genetic stability confirmed.
    • Attenuated Sm-d mutants demonstrated stable attenuation in mice following intraperitoneal administration.
    • Live, restricted-reproducing Pasteurella multocida exhibited enhanced immunogenicity compared to thermally inactivated antigens.

    Impact:

    • Provides a foundation for developing effective Pasteurella multocida vaccines for cattle.
    • Highlights the potential of live attenuated vaccines over traditional inactivated vaccines.
    • Contributes to understanding bacterial attenuation and immunogenicity for improved animal health strategies.