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[Transplantation immunology].

H D Volk1, P Reinke

  • 1Institut für Medizinische Immunologie, Universitätsklinikum Charité der Humboldt-Universität zu Berlin.

Zeitschrift Fur Arztliche Fortbildung Und Qualitatssicherung
|June 4, 1999
PubMed
Summary
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Preventing allograft rejection requires managing various types, including acute and chronic forms. Early diagnosis of acute rejection and controlling viral infections like CMV are crucial for long-term graft survival.

Area of Science:

  • Immunology
  • Transplantation Medicine
  • Infectious Diseases

Context:

  • Allogeneic grafts face immunological attacks: hyperacute, accelerated, acute, and chronic rejection.
  • Clinical advancements like pre-transplant crossmatch have eliminated hyperacute rejection.
  • New immunosuppressive agents improve accelerated and early acute rejection management.

Purpose:

  • To enhance the diagnosis of early and late acute rejection to prevent chronic rejection.
  • To highlight the role of cytomegalovirus (CMV) infection in chronic rejection.
  • To explore strategies for reducing peri-operative inflammatory processes.

Summary:

  • Hyperacute rejection is prevented by pre-transplant crossmatching.
  • New immunosuppressants aid in managing accelerated and acute rejection.

Related Experiment Videos

  • Improved diagnostics and managing CMV infections are key to preventing chronic rejection.
  • Controlling ischemia/reperfusion injury-induced inflammation is another strategy.

    • Impact:

    • Advances in immunosuppression and diagnostics are improving graft survival rates.
    • Recognizing CMV as a chronic rejection risk factor enables targeted antiviral therapy.
    • Reducing inflammatory responses post-transplant contributes to better long-term outcomes.