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Exfoliative cytology in screening for malignant and premalignant lesions in the buccal mucosa
T Ramaesh1, N Ratnatunga, B R Mendis
1Department of Basic Sciences, Faculty of Dental Sciences, University of Peradeniya.
Objective:
To test the efficacy of exfoliative cytology in the detection of oral premalignant and malignant lesions.
Design:
Cytological diagnosis of lesions of the buccal mucosa assessed using histopathological diagnosis of the same lesions as the gold standard.
Subjects:
Patients with buccal lesions clinically diagnosed as leukoplakia (n = 91) and squamous cell carcinoma (SCC, n = 59), and healthy subjects (n = 40) in whom buccal mucosa appeared clinically normal.
Setting:
Oral and Maxillo-facial Unit, General Hospital, Kandy and Department of Pathology, Faculty of Medicine, University of Peradeniya.
Results:
A sensitivity of 77%, specificity of 100% and accuracy of 92% were obtained for leukoplakia. SCC gave a sensitivity of 94%, specificity of 100% and an accuracy of 95%.
Conclusions:
Oral exfoliative cytology is a useful method for detecting oral premalignant and malignant lesions. Anucleated squames in a smear is non-diagnostic.
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