Jove
Visualize
Contact Us

Related Experiment Videos

Clinical experience with oral ketamine.

M C Enarson1, H Hays, M A Woodroffe

  • 1Department of Family Medicine, University of Alberta, Edmonton, Canada.

Journal of Pain and Symptom Management
|June 4, 1999
PubMed
Summary

Oral ketamine shows potential for chronic neuropathic pain relief, though side effects limit use for some. Long-term benefits were observed in a subset of patients, particularly those with shorter pain durations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Home care of the frail elderly and the terminally ill.

Canadian family physician Medecin de famille canadien·2011
Same author

Hypodermoclysis for symptom control in terminal care.

Canadian family physician Medecin de famille canadien·2011
Same author

High dosing methadone and a possible relationship to serious cardia arrhythmias.

Pain research & management·2002
Same author

Marijuana for the management of proximal mytonic myopathy.

Journal of pain and symptom management·2001
Same author

Randomised crossover trial of transdermal fentanyl and sustained release oral morphine for treating chronic non-cancer pain.

BMJ (Clinical research ed.)·2001
Same author

Using gabapentin to treat neuropathic pain.

Canadian family physician Medecin de famille canadien·1999
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Pharmacology
  • Neurology
  • Pain Management

Background:

  • Ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, is increasingly explored for analgesia.
  • Chronic neuropathic pain presents a significant therapeutic challenge, often requiring novel treatment approaches.

Purpose of the Study:

  • To evaluate the analgesic efficacy and side effect profile of oral ketamine in patients with chronic neuropathic pain.
  • To identify patient characteristics that may predict response to oral ketamine therapy.

Main Methods:

  • Retrospective chart review of 21 patients with chronic neuropathic pain treated with oral ketamine.
  • Dosing started at 100 mg/day, titrated upwards based on efficacy or side effects.
  • Analysis of treatment outcomes, including pain relief, side effects, and duration of use.

Main Results:

  • Nine patients discontinued ketamine due to intolerable side effects.
  • Four patients experienced no discernible pain relief.
  • Four patients continued long-term oral ketamine use (over 1 year) with reported pain improvement and reduced analgesic use, particularly those with pain histories under 5 years.

Conclusions:

  • Oral ketamine offers potential benefits for chronic neuropathic pain, but tolerability and efficacy vary significantly among patients.
  • Further research is warranted to optimize ketamine dosing and patient selection for chronic pain management.
  • The duration of pain history may influence the effectiveness of oral ketamine for analgesia.

Related Experiment Videos