Tri-isobutylphosphate: a prenatal toxicity study in rats

Area of Science:

• Toxicology
• Reproductive Toxicology
• Developmental Toxicology

Background:

• Tri-isobutylphosphate (CAS 126-71-6) is an anti-foaming agent.
• Assessing its prenatal toxicity is crucial for safety evaluation.

Purpose of the Study:

• To evaluate the prenatal toxicity of tri-isobutylphosphate in pregnant rats.
• To determine potential embryotoxic or teratogenic effects.

Main Methods:

• Pregnant rats were administered daily oral doses (0, 100, 300, 1000 mg/kg) from day 6 to 15 of gestation.
• Maternal and fetal examinations were conducted on day 20 of pregnancy.

Main Results:

• Maternal effects included dose-related salivation and increased water consumption at the highest dose.
• No statistically significant impact on body weight gain was observed.
• No embryotoxic or teratogenic effects were detected in fetuses or litters.
• A cluster of 'hunched posture syndrome' was observed but considered coincidental.

Conclusions:

• Tri-isobutylphosphate did not demonstrate significant prenatal toxicity or teratogenicity in rats.
• The lowest observed adverse effect level (LOAEL) or no observed adverse effect level (NOAEL) for maternal effects requires further interpretation of salivation.
• Observed fetal abnormalities were likely coincidental and not treatment-related.