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Antitussive effect of K+ channel openers
R Poggioli1, A Benelli, R Arletti
1Department of Biomedical Sciences, University of Modena and Reggio nell'Emilia, Italy.
European Journal of Pharmacology
|June 4, 1999
Summary
Potassium channel openers, pinacidil and cromakalim, effectively reduced coughing in guinea pigs, showing an opioid-like antitussive effect. This suggests a potential new approach for cough symptom treatment.
Area of Science:
- Pharmacology
- Respiratory Medicine
- Neuroscience
Background:
- Coughing is a common symptom with limited effective treatments.
- K(ATP) channels are involved in various physiological processes, including smooth muscle relaxation.
Purpose of the Study:
- To investigate the antitussive effects of K(ATP) channel openers, pinacidil and cromakalim.
- To compare their efficacy with codeine and explore potential additive effects.
Main Methods:
- Guinea pigs were exposed to citric acid-induced cough.
- Pinacidil and cromakalim were administered subcutaneously.
- Antitussive effects were quantified by calculating the D50 values.
Main Results:
- Both pinacidil and cromakalim significantly inhibited coughing.
- Their effects were additive when combined with codeine or a tachykinin NK2 receptor antagonist.
- No bronchodilating effects were observed at the tested doses.
Conclusions:
- K(ATP) channel openers possess opioid-like antitussive properties.
- These compounds represent a potential novel therapeutic strategy for managing cough symptoms.