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Related Experiment Videos

Decrease in P-selectin levels in patients with hypercholesterolaemia and peripheral arterial occlusive disease after

G Kirk1, M McLaren, A H Muir

  • 1Section of Vascular Medicine and Biology, University Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK.

Vascular Medicine (London, England)
|June 4, 1999
PubMed
Summary

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Fluvastatin significantly reduced soluble P-selectin (sP-selectin) levels in patients with peripheral arterial occlusive disease (PAOD). This suggests fluvastatin may help slow atherosclerosis and decrease platelet activation in PAOD patients.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Peripheral arterial occlusive disease (PAOD) is linked to elevated cholesterol, triglycerides, and soluble P-selectin (sP-selectin).
  • Increased sP-selectin indicates platelet and endothelial cell activation at sites of vascular injury.

Purpose of the Study:

  • To investigate the effect of fluvastatin on sP-selectin levels in patients with PAOD and hypercholesterolemia.

Main Methods:

  • A 12-week study involving 31 PAOD patients with hypercholesterolemia.
  • Patients received either fluvastatin or a placebo.
  • sP-selectin levels were measured before and after treatment.

Main Results:

  • Fluvastatin treatment significantly lowered sP-selectin levels (157.0 to 113.77 ng/ml, p=0.01).

Related Experiment Videos

  • Placebo treatment showed no significant change in sP-selectin levels (150.0 to 139.4 ng/ml).
  • Patients switched from placebo to fluvastatin also showed significant reduction in sP-selectin.

    • Conclusions:

    • Fluvastatin effectively reduces sP-selectin levels in PAOD patients.
    • Lowering sP-selectin may attenuate atherosclerotic progression and decrease platelet activation in PAOD.