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Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
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Genetics of mouse behavior: interactions with laboratory environment.

J C Crabbe1, D Wahlsten, B C Dudek

  • 1Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, Portland, OR 97201, USA. crabbe@ohsu.edu

Science (New York, N.Y.)
|June 5, 1999
PubMed
Summary

Laboratory environment significantly impacts neurobehavioral genetics research. Standardized testing across labs revealed systematic differences, suggesting results may be lab-specific, especially for mutant characterization.

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Area of Science:

  • Neurobehavioral Genetics
  • Laboratory Animal Science
  • Behavioral Phenotyping

Background:

  • Inbred mouse strains are crucial models for neurobehavioral genetics research.
  • Laboratory environmental factors can potentially confound behavioral studies.
  • Understanding environmental influences is key to reliable genetic research.

Purpose of the Study:

  • To investigate the influence of the laboratory environment on behavioral phenotypes in mice.
  • To assess the impact of inter-laboratory variation on behavioral genetics studies.
  • To determine if genetic differences are consistent across different testing environments.

Main Methods:

  • Simultaneous testing of multiple inbred mouse strains and a null mutant.
  • Utilized a standardized battery of six behavioral tests.
  • Equated apparatus, test protocols, and environmental variables across three distinct laboratories.

Main Results:

  • Significant strain-specific differences in all tested behaviors were observed.
  • Despite rigorous standardization, systematic behavioral differences were detected across laboratories.
  • The magnitude of observed genetic effects varied depending on the specific testing laboratory for certain behaviors.

Conclusions:

  • Laboratory environment introduces systematic variability into mouse behavioral studies.
  • Standardization efforts may not fully eliminate inter-laboratory differences in behavioral outcomes.
  • Results from mutant characterization studies may be idiosyncratic to the specific laboratory where they were conducted.