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Related Experiment Videos

Circulating lymphocyte subsets in obsessive compulsive disorder, major depression and normal controls.

A V Ravindran1, J Griffiths, Z Merali

  • 1Department of Psychiatry, University of Ottawa, Institute of Mental Health Research at the Royal Ottawa Hospital, Ontario, Canada.

Journal of Affective Disorders
|June 5, 1999
PubMed
Summary

Major depression and obsessive compulsive disorder (OCD) show elevated natural killer (NK) cells, particularly in males. While NK cell levels normalize with treatment in depression, they remain elevated in OCD patients, suggesting a potential trait characteristic.

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Area of Science:

  • Neuroscience
  • Immunology
  • Psychiatry

Background:

  • Obsessive compulsive disorder (OCD) shares clinical and therapeutic similarities with major depressive disorder.
  • Investigating immune alterations, specifically circulating natural killer (NK) cells, in OCD is crucial for understanding its pathophysiology.

Purpose of the Study:

  • To determine if obsessive compulsive disorder (OCD) patients exhibit elevated circulating natural killer (NK) cells, similar to major depressive disorder patients.
  • To assess the impact of stress perception and coping styles on NK cell alterations in these patient groups.
  • To evaluate the effect of antidepressant treatment on symptoms and NK cell levels in both OCD and major depressive disorder.

Main Methods:

  • Blood samples were collected from OCD patients, major depressive patients, and age/sex-matched controls to quantify circulating lymphocytes.

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  • Patients completed assessments for stress perception and coping styles.
  • A subset of patients was re-evaluated after 12 weeks of serotonergic reuptake inhibitor treatment.

    • Main Results:

    • Both major depressive and OCD patients reported higher stress perception and used emotion-focused coping strategies.
    • Elevated circulating NK cells were observed in male patients with OCD and major depression, with a modest increase in female major depressives.
    • Antidepressant treatment reduced symptoms and normalized NK cells in major depressives, but not in OCD patients.

    Conclusions:

    • Elevated NK cells are present in both major depression and OCD (males), but normalization post-treatment is specific to depression.
    • Persistent NK cell elevation in OCD patients may indicate a trait marker or incomplete remission.
    • Further research is needed to assess other immune markers for a comprehensive understanding of immune status in OCD.