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A naturalistic comparison of adverse effects between slow titration and loading of divalproex sodium in psychiatric
W J Lima1, J A Dopheide, B A Kramer
1University of Southern California, School of Pharmacy, Los Angeles, USA.
Background:
This study compares the incidence, severity and onset of treatment-emergent adverse effects between slow titration and loading of divalproex sodium in psychiatric inpatients.
Method:
Forty-seven patients were prescribed either loading or slow titration of divalproex sodium. Under single-blind conditions, adverse effects were assessed using a valproate adverse effects rating scale. Except for a statistically significant greater incidence of somnolence in the slow titration group, no statistically or clinically significant differences in incidence, severity or onset of treatment-emergent adverse effects were found between groups.
Results/Conclusion:
Overall, adverse effects were well tolerated by both groups.
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