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Related Experiment Videos

Recall rendered dependent on an opiate state.

L A Bruins Slot1, F C Colpaert

  • 1Centre de Recherche Pierre Fabre, Castres, France.

Behavioral Neuroscience
|June 5, 1999
PubMed
Summary

Morphine induces state dependence (StD), where learning is recalled only in the drug state present during training. This StD mechanism may explain how opiates produce their analgesic effects.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Psychology

Background:

  • State dependence (StD) suggests memory recall is optimal in the same physiological state as learning.
  • Opiates, like morphine, are known for their analgesic properties.

Purpose of the Study:

  • To investigate if morphine induces state dependence in rats.
  • To determine if morphine-induced state dependence contributes to opiate analgesia.

Main Methods:

  • Rats were trained on a learned response under morphine or in a nondrugged state.
  • Recall of the learned response was tested in both drugged and nondrugged states.
  • Morphine analgesia was assessed in relation to dose and time.

Main Results:

  • Rats trained with morphine recalled the response only when tested with morphine, not when drug-free.
  • Rats trained drug-free recalled the response only when tested drug-free, not with morphine.
  • The dose-response and time course of morphine analgesia mirrored that of state dependence.

Conclusions:

  • Morphine reliably induces state dependence in rats.
  • State dependence may be the psychophysiological mechanism underlying opiate analgesia.
  • This finding has implications for understanding how opiates affect learned responses to pain.

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