Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease in linoleic acid metabolites as a potential mechanism in cancer risk reduction by conjugated linoleic acid.

S Banni1, E Angioni, V Casu

  • 1Dipartimento di Biologia Sperimentale, Sezione di Patologia Sperimentale, Universita degli Studi di Cagliari, Cittadella Universitaria, 09042 Monserrato, Cagliari, Italy.

Carcinogenesis
|June 5, 1999
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic, epigenetic, and electrophysiological markers of serotonergic function and SSRI-related nausea.

Journal of affective disorders·2026
Same author

Author Correction: Enteric α-synuclein impairs intestinal epithelial barrier through caspase-1-inflammasome signaling in Parkinson's disease before brain pathology.

NPJ Parkinson's disease·2023
Same author

Localized waves in elastic plates with perturbed honeycomb arrays of constraints.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2022
Same author

Enteric α-synuclein impairs intestinal epithelial barrier through caspase-1-inflammasome signaling in Parkinson's disease before brain pathology.

NPJ Parkinson's disease·2022
Same author

Supercritical extraction of volatile and fixed oils from <i>Petroselinum crispum</i> L. seeds: chemical composition and biological activity.

Natural product research·2020
Same author

How to demystify COVID-19 and reduce social stigma.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2020

Conjugated linoleic acid (CLA) reduces mammary tumor risk by decreasing terminal end bud density in rats. CLA also lowers arachidonic acid levels, a key factor in eicosanoid biosynthesis and cancer development.

Area of Science:

  • Nutritional Biochemistry
  • Cancer Biology
  • Mammalian Physiology

Background:

  • Conjugated linoleic acid (CLA) feeding during mammary gland development may reduce cancer risk.
  • Terminal end buds (TEBs) are primary sites for mammary carcinogenesis in rodents.

Purpose of the Study:

  • Investigate CLA's modulation of TEB density.
  • Determine CLA's effect on methylnitrosourea-induced mammary carcinogenesis.
  • Elucidate the biochemical mechanisms of CLA's action.

Main Methods:

  • Dietary administration of varying CLA levels (0.5-2%) to rats.
  • Assessment of TEB density and mammary tumor yield.
  • Fatty acid analysis of mammary tissue lipids.

Main Results:

Related Experiment Videos

  • A dose-dependent reduction in TEB density and tumor yield was observed with 0.5% and 1% CLA.
  • Higher CLA levels (1.5-2%) did not yield further decreases.
  • CLA accumulation in mammary tissue correlated with decreased linoleic acid metabolites, notably arachidonic acid.

Conclusions:

  • Optimal CLA nutrition during pubescence can control mammary gland cancer-sensitive sites.
  • CLA's cancer-protective effect may be linked to suppressed arachidonic acid metabolism.
  • CLA interferes with linoleic acid metabolism, impacting eicosanoid biosynthesis.