Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytoplasmic polyadenylation in development and beyond.

J D Richter1

  • 1Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA. Joel.Richter@ummed.edu

Microbiology and Molecular Biology Reviews : MMBR
|June 5, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CPEB1 mediates epithelial-to-mesenchyme transition and breast cancer metastasis.

Oncogene·2015
Same author

Translational control of embryonic cell division by CPEB and maskin.

Cold Spring Harbor symposia on quantitative biology·2003
Same author

A role for the cytoplasmic polyadenylation element in NMDA receptor-regulated mRNA translation in neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
Same author

New ways of initiating translation in eukaryotes.

Molecular and cellular biology·2001
Same author

Germ cell differentiation and synaptonemal complex formation are disrupted in CPEB knockout mice.

Developmental cell·2001
Same author

CPEB phosphorylation and cytoplasmic polyadenylation are catalyzed by the kinase IAK1/Eg2 in maturing mouse oocytes.

Development (Cambridge, England)·2001
Same journal

Structure, assembly, and mechanism of the MmpL family of transporters.

Microbiology and molecular biology reviews : MMBR·2026
Same journal

Killer meiotic drivers in fungi.

Microbiology and molecular biology reviews : MMBR·2026
Same journal

From dividing to dormant: embracing the full activity spectrum for environmental microorganisms.

Microbiology and molecular biology reviews : MMBR·2026
Same journal

Role of TMDs in Class I viral fusion proteins.

Microbiology and molecular biology reviews : MMBR·2026
Same journal

The microbiome in reptile health, disease, and ecology.

Microbiology and molecular biology reviews : MMBR·2026
Same journal

Overcoming the energy-dependent barrier to aminoglycoside uptake: multimodal strategies to sensitize <i>Staphylococcus aureus</i> persisters.

Microbiology and molecular biology reviews : MMBR·2026
See all related articles

Cytoplasmic polyadenylation regulates maternal mRNA translation, crucial for development and brain function. Research is clarifying its biochemical mechanisms and roles in processes like learning and memory.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Neuroscience

Background:

  • Maternal mRNA translation is primarily controlled by cytoplasmic polyadenylation.
  • This process is vital for key events such as meiosis and embryonic body patterning in both vertebrates and invertebrates.
  • While evolutionarily conserved, specific cis elements and trans-acting factors exhibit species specificity.

Purpose of the Study:

  • To elucidate the biochemical mechanisms underlying cytoplasmic polyadenylation reactions, including poly(A) elongation and deadenylation.
  • To explore the role of cytoplasmic polyadenylation beyond early development, specifically in the adult brain.
  • To investigate the potential involvement of cytoplasmic polyadenylation in synaptic plasticity, learning, and memory.

Main Methods:

Related Experiment Videos

  • Isolation and cloning of factors involved in poly(A) tail elongation.
  • Isolation and cloning of factors involved in poly(A) tail deadenylation.
  • Biochemical analysis of polyadenylation and deadenylation reactions.

    • Main Results:

    • The underlying biochemistry of poly(A) elongation and deadenylation is beginning to be understood.
    • Cytoplasmic polyadenylation is active in the adult brain.
    • Evidence suggests a role for cytoplasmic polyadenylation at synapses, potentially mediating long-term potentiation.

    Conclusions:

    • Cytoplasmic polyadenylation is a fundamental regulatory mechanism with conserved and species-specific aspects.
    • This process extends beyond embryonic development to influence adult brain function, including synaptic plasticity.
    • Further research is needed to fully understand the multifaceted roles and mechanisms of cytoplasmic polyadenylation.