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Related Experiment Videos

Anaplastic large cell lymphoma: a concept reviewed.

Pileri1, Milani, Ascani

  • 1Anatomical Pathology and Hematopathology Institute, University of Bologna, Bologna, 40138, Italy. pileri@almadns.unibo.it

Advances in Clinical Pathology : the Official Journal of Adriatic Society of Pathology
|June 8, 1999
PubMed
Summary

This review covers anaplastic large cell lymphoma (ALCL) subtypes and morphology. It highlights recent genetic discoveries, like the NPM/ALK fusion gene, impacting future classification and treatment.

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Immunology today·1999

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Anaplastic large cell lymphoma (ALCL) is a distinct non-Hodgkin lymphoma.
  • Understanding ALCL subtypes and their characteristics is crucial for accurate diagnosis and treatment.

Purpose of the Study:

  • To review the evolution of the ALCL concept.
  • To discuss proposed ALCL subtypes, including the Hodgkin's-like variant.
  • To present recent genetic and molecular findings and their clinical implications.

Main Methods:

  • Literature review of ALCL development and classification.
  • Morphological and clinical analysis of ALCL subtypes.
  • Summary of genetic and molecular data, including translocations and hybrid genes.

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Main Results:

  • Morphological and clinical features of various ALCL subtypes are detailed.
  • Key genetic alterations such as the t(2;5) translocation are discussed.
  • The formation of the NPM/ALK hybrid gene and its protein product are presented.

Conclusions:

  • Recent genetic and molecular findings offer new insights into ALCL.
  • These discoveries have potential implications for future ALCL classification.
  • Understanding molecular drivers may guide improved clinical management strategies for ALCL.