[Mitochondrial energy metabolism, uncoupling proteins and adipose tissue accumulation]

New possibilities are explored for supporting classical treatment of obesity. There are three main ways for the pharmacotherapy of obesity: (1) inhibition of absorption of nutrients in the intestine; (2) modulation of the activity of hypothalamic centra controlling satiety and food consumption; and (3) induction of energy dissipation in tissues (thermogenesis). The last possibility received more attention due to recent discoveries. The goal would be to affect mitochondrial energy conversion in a way leading to elevated thermogenesis and not to ATP production.