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[Diovan efficacy and tolerance in mild and moderate hypertension]

A N Zakirova, N E Zakirova

    Terapevticheskii Arkhiv
    |June 8, 1999
    PubMed

    Insights

    Diovan (valsartan), an angiotensin-II antagonist, effectively lowers blood pressure in patients with mild to moderate hypertension. This study found it safe and well-tolerated over an 8-week treatment period.

    Area of Science:

    • Cardiovascular Medicine
    • Pharmacology

    Background:

    • Hypertension is a significant global health concern.
    • Angiotensin-II antagonists represent a key therapeutic class for managing blood pressure.

    Purpose of the Study:

    • To evaluate the clinical effectiveness of Diovan (valsartan) in patients with mild to moderate hypertension.
    • To assess the safety and tolerance profile of Diovan (valsartan) in this patient group.

    Main Methods:

    • A trial involving 20 patients (mild to moderate hypertension) was conducted over 8 weeks.
    • Patients received Diovan (valsartan) at 80 mg/day, with a potential increase to 160 mg/day if needed.
    • Clinical effectiveness was measured by changes in systolic and diastolic blood pressure.

    Main Results:

    • A significant reduction in both systolic and diastolic blood pressure was observed within 2 weeks.
    • The blood pressure-lowering effect was enhanced by week 8.
    • 90% of patients achieved a diastolic blood pressure of 90 mm Hg or a 10% reduction.

    Conclusions:

    • Diovan (valsartan) demonstrated significant efficacy in treating mild to moderate hypertension.
    • The medication was well-tolerated, with no adverse metabolic changes reported.
    Abstract

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