[Infectious endocarditis: immune disorders, differentiated therapy]

Immunological assessment of variants of infectious endocarditis (IE) and design of differentiated approach to the disease therapy.

Of 150 patients treated (90 males and 60 females, mean age 41.9 +/- 3.3 years) 28.7% and 71.3% had primary and secondary endocarditis, respectively. With chronization of the process, there was a trend to growing immune unbalance (IU).

The IU in IE patients manifested with leukocytosis changing for leukopenia, reduced absolute and relative number of lymphocytes, complement, T- and B-lymphocytes, growing content of CIC, IgM, rheumatoid factor and cryoproteins.

Besides antibacterial therapy, IE patients need immunocorrective and efferent therapy.