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Related Experiment Videos

Phospholipase D structure and regulation.

M A Frohman1, A J Morris

  • 1Department of Pharmacological Sciences, SUNY at Stony Brook 11794-8651, USA. michael@pharm.som.sunysb.edu

Chemistry and Physics of Lipids
|June 8, 1999
PubMed
Summary
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New research on phospholipase D (PLD) reveals its structure and regulation. PLD, encoded by two genes, plays a role in secretion and membrane biogenesis.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Phospholipase D (PLD) is an enzyme implicated in cellular signaling.
  • Recent advancements include the identification of cDNA clones for PLD.

Purpose of the Study:

  • To investigate the structure and regulation of phospholipase D.
  • To understand the in vivo roles of PLD in cellular processes.

Main Methods:

  • Identification of cDNA clones for phospholipase D.
  • Analysis of gene structures encoding PLD activity.
  • Investigation of enzymatic mechanisms related to phosphodiesterases.

Main Results:

  • At least two different genes encode phospholipase D activity.

Related Experiment Videos

  • PLD catalytic domains share similarities with phosphodiesterases.
  • In vivo studies suggest PLD involvement in regulated secretion and membrane biogenesis.

    • Conclusions:

    • The identification of PLD cDNA clones facilitates further research into its function.
    • PLD is likely a key regulator in cellular secretion and membrane formation.