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Serotonin and externalizing behavior in young children.

R A Clarke1, D L Murphy, J N Constantino

  • 1Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO 63110, USA.

Psychiatry Research
|June 8, 1999
PubMed
Summary
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Low serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in newborns is linked to increased aggressive behavior by 30 months. This suggests serotonin

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Behavioral Genetics

Background:

  • Pathologic aggressive behavior is linked to low cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) in primates and humans.
  • Serotonin is a key neurotransmitter implicated in mood and behavior regulation.

Purpose of the Study:

  • To investigate the relationship between newborn CSF 5-HIAA levels and aggressive behavior at 30 months of age.
  • To explore the role of serotonin in early development of antisocial tendencies.

Main Methods:

  • CSF samples from febrile infants (0-3 months) were analyzed for 5-HIAA concentrations.
  • Child behavior and family environment were assessed at 30 months via parent reports.

Main Results:

Related Experiment Videos

  • Infants with below-median 5-HIAA levels exhibited significantly higher externalizing behavior scores at 30 months (P = 0.02).
  • Lower newborn 5-HIAA is associated with increased aggressive tendencies later in childhood.

Conclusions:

  • Serotonin may contribute to genetic liability for antisocial outcomes, but its influence might be less than previously suggested.
  • Early life serotonin levels could be a biomarker for later behavioral issues.