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The force exerted by a molecular motor.

M E Fisher1, A B Kolomeisky

  • 1Institute for Physical Science and Technology, University of Maryland, College Park, MD 20742, USA.

Proceedings of the National Academy of Sciences of the United States of America
|June 9, 1999
PubMed
Summary

This study introduces a general "barometric" relation for molecular motor driving force, applicable across models and consistent with load-dependent behavior. It reveals diverse velocity-load relationships and invalidates prior force bounds.

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Area of Science:

  • Biophysics
  • Molecular Motors
  • Statistical Mechanics

Background:

  • Single molecular motors generate force through stochastic processes on periodic tracks like microtubules and actin filaments.
  • Understanding this driving force is crucial for cellular mechanics and motility.
  • Existing models often require specific assumptions about motor kinetics and load interactions.

Purpose of the Study:

  • To introduce a general, experimentally testable relation for the stochastic driving force of molecular motors.
  • To unify diverse kinetic and stochastic models under a single framework.
  • To explore the relationship between motor velocity, load, and diffusion coefficients.

Main Methods:

  • Development of a general "barometric" relation for molecular motor driving force.

Related Experiment Videos

  • Analysis of kinetic and stochastic models, including discrete jump models.
  • Investigation of motor velocity-load relationships and their dependence on model parameters.
  • Comparison with existing theoretical bounds on motor driving force.

    • Main Results:

    • A universal "barometric" relation for driving force is established, valid for various models.
    • The relation is consistent with detailed models and reduces to an Einstein-type relation near equilibrium.
    • Velocity-load plots show diverse behaviors, including non-monotonicity, even in simple models.
    • Previously proposed bounds on driving force are demonstrated to be generally inapplicable.

    Conclusions:

    • The proposed "barometric" relation offers a unifying framework for studying molecular motor mechanics.
    • The diverse velocity-load characteristics highlight the complexity of motor function under load.
    • The findings necessitate a re-evaluation of theoretical constraints on molecular motor performance.