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Application of Hemostatic Devices in Laparoscopic Hepatectomy
Published on: April 19, 2022
Successful liver transplantation after induction chemotherapy in children with inoperable, multifocal primary hepatic
J Laine1, H Jalanko, U M Saarinen-Pihkala
1Hospital for Children and Adolescents, University of Helsinki, Finland.
Background:
The prognosis for primary epithelial liver tumor in children in whom radical surgery cannot be performed after chemotherapy is poor. Orthotopic liver transplantation has resulted in mortality up to 50%, largely as a result of problems in determining the criteria for transplantation.
Methods:
We report results on liver transplantation for primary epithelial liver malignancy in five children (mean age at transplantation: 6.0 years). Only patients with inoperable residual tumor in the liver after four cycles of multidrug chemotherapy, but without extrahepatic infiltration or metastases, were considered eligible for transplantation.
Results:
Mean follow-up was 4.6 years. Patient and graft survival was 100%, with no signs of residual or de novo malignancy.
Conclusion:
In children with inoperable primary liver malignancy with no extrahepatic tumor growth, orthotopic liver transplantation has an excellent outcome.
