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Related Experiment Videos

Posttransplantation B lymphoblastic leukemia with Burkitt-like features.

D A Tweddle1, A R Gennery, M M Reid

  • 1Department of Child Health, Royal Victoria Infirmary, Newcastle, United Kingdom. D.A.Tweddle@newcastle.ac.uk

Transplantation
|June 9, 1999
PubMed
Summary

Posttransplantation lymphoproliferative disease (PTLPD) can manifest as acute lymphoblastic leukemia, a rare presentation. Bone marrow examination is crucial for diagnosing PTLPD in transplant patients.

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Area of Science:

  • Immunology
  • Oncology
  • Transplantation Medicine

Background:

  • Posttransplantation lymphoproliferative disease (PTLPD) is a spectrum of lymphoid disorders post-transplant.
  • PTLPD ranges from benign hyperplasia to aggressive lymphoma.
  • PTLPD has not been previously reported as acute lymphoblastic leukemia.

Observation:

  • A pediatric cardiac transplant recipient developed PTLPD 6 years post-transplant.
  • The patient presented with acute lymphoblastic leukemia.
  • Bone marrow showed >90% Epstein-Barr virus-positive B lymphoblasts with Burkitt-like features and t(8;14) translocation.

Findings:

  • The patient received combination chemotherapy.
  • The treatment was successful in managing the leukemia.

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  • The patient unfortunately died from ischemic heart disease 6 months post-treatment.

    • Implications:

    • Acute lymphoblastic leukemia can be a manifestation of PTLPD.
    • PTLPD classification should include B lymphoblastic leukemia.
    • Bone marrow examination is essential for PTLPD diagnosis in suspicious cases.