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Clinical application of a new assisted hatching method using a piezo-micromanipulator for morphologically low-quality
T Nakayama1, H Fujiwara, S Yamada
1Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Japan.
Objective:
To assess the effect of a assisted hatching technique using a piezo-micromanipulator on pregnancy rates in poor-prognosis infertile patients.
Design:
A prospective randomized study.
Setting:
The Infertility and IVF unit of the Kyoto University Hospital.
Patient(S):
Infertile patients who had been treated for >4 years and failed in previous IVF trials at least twice.
Intervention(S):
Two hundred forty-eight IVF cycles from 173 patients were divided into two groups: cycles with the transfer of embryos treated by assisted hatching and cycles with the transfer of nontreated embryos. Each group was subdivided into two groups according to embryo morphology: cycles in which three or two morphologically good-quality embryos were transferred and cycles in which one or no morphologically good-quality embryos were transferred. Assisted hatching was performed by a piezo-micromanipulator.
Main Outcome Measure(S):
The clinical pregnancy rates and implantation rates.
Result(S):
The clinical pregnancy and implantation rates were significantly higher in the assisted hatching group of patients with three or two good-quality embryos than in the other three groups.
Conclusion(S):
The assisted hatching using a piezo-micromanipulator improved the pregnancy and implantation rates in poor-prognosis infertile patients with good-quality embryo transfer but had no effect in patients with low-quality embryo transfer.