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Isradipine and insulin sensitivity in hypertensive rats
M Pĭtre1, N Gaudreault, M Santuré
1Hypertension Research Unit, Laval University Medical Research Center, Centre Hospitalier de l'Université, Laval University, Ste-Foy, Quebec, Canada G1V 4G2.
The American Journal of Physiology
|June 11, 1999
Summary
Isradipine, a blood pressure-lowering drug, improved insulin sensitivity and vascular responses in hypertensive rats. This suggests hemodynamic factors play a key role in these beneficial effects.
Area of Science:
- Cardiovascular Pharmacology
- Metabolic Physiology
Background:
- Hypertension is linked to impaired insulin sensitivity.
- Calcium channel blockers may influence metabolic and vascular functions.
Purpose of the Study:
- To investigate the effects of isradipine on insulin sensitivity and vascular responses in spontaneously hypertensive rats (SHR).
Main Methods:
- Rats were treated with isradipine or vehicle.
- Blood pressure, heart rate, and blood flow were measured.
- Insulin sensitivity was assessed using the euglycemic-hyperinsulinemic clamp technique.
Main Results:
- Isradipine significantly reduced blood pressure and improved insulin sensitivity.
- Isradipine treatment led to vasodilation in multiple vascular beds.
- Insulin-induced vasoconstriction in SHR was attenuated by isradipine.
Conclusions:
- Short-term isradipine treatment lowers blood pressure and enhances insulin sensitivity in SHR.
- Hemodynamic improvements appear to be the primary mechanism behind these effects.