Related Experiment Videos
[Hyalinizing trabecular adenoma of the thyroid]
D Hardisson Hernáez1, M P Prim Espada, J I De Diego Sastre
1Departamento de Anatomía Patológica, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid, España.
Acta Otorrinolaringologica Espanola
|June 11, 1999
Summary
Hyalinizing trabecular adenoma (HTA) is a rare thyroid tumor. This case report details its presentation, histology, and successful treatment with hemithyroidectomy, showing a positive prognosis.
Area of Science:
- Endocrinology
- Surgical Pathology
- Oncology
Background:
- Hyalinizing trabecular adenoma (HTA) is a recently described, rare tumor originating from thyroid follicular cells.
- Accurate diagnosis is crucial as HTA can be mistaken for other thyroid malignancies like medullary or papillary carcinoma, or even paraganglioma.
- Understanding HTA's distinct histological and immunohistochemical features aids in its differentiation from aggressive thyroid neoplasms.
Observation:
- A 25-year-old woman presented with a <
> on radionuclide scans, localized to the left thyroid lobe. - Histopathological examination revealed a tumor with a characteristic trabecular pattern embedded within a prominent hyaline stroma.
- Immunohistochemical analysis showed focal thyroglobulin reactivity, while calcitonin, chromogranin, and S-100 protein were negative.
Findings:
- The histological and immunohistochemical profile confirmed the diagnosis of hyalinizing trabecular adenoma.
- The patient underwent hemithyroidectomy for treatment of the thyroid nodule.
- Post-operative follow-up for three years showed the patient to be alive and disease-free, indicating a favorable outcome.
Implications:
- This case highlights the importance of recognizing the unique features of HTA in thyroid nodule diagnosis.
- Successful surgical management (hemithyroidectomy) resulted in a complete recovery, suggesting HTA is generally benign.
- Further studies on HTA are warranted to fully elucidate its pathogenesis and long-term behavior.