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Updated: Aug 8, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Ischemic venous thrombosis: its hidden agenda
1Ohio State University Medical Center, Columbus 43210, USA.
Summary
Ischemic venous thrombosis (IVT), a severe condition, strongly associates with cancer, often preceding its diagnosis. This rare condition, particularly in the lower extremities, carries a high mortality rate and may indicate an underlying malignancy.
Area of Science:
- Vascular Surgery
- Oncology
- Thrombosis Research
Background:
- Ischemic venous thrombosis (IVT) represents the most severe form of venous thrombosis.
- IVT is a rare clinical condition with significant morbidity and mortality.
- The association between IVT and underlying malignancy is increasingly recognized.
Purpose of the Study:
- To describe the clinical characteristics of ischemic venous thrombosis.
- To review cases of lower extremity IVT and their association with cancer.
- To highlight IVT as a potential early marker for undiagnosed malignancies.
Main Methods:
- Retrospective review of 14 cases of lower extremity IVT.
- Analysis of patient demographics, risk factors, clinical presentation, and outcomes.
- Emphasis on the correlation between IVT and the presence of cancer.
Main Results:
- Malignancy was identified in 86% of patients, often diagnosed after IVT onset.
- Venous gangrene occurred in 79% of cases, leading to amputations.
- The overall mortality rate was high at 71%, with a significant proportion of deaths within two months of diagnosis.
Conclusions:
- A strong association exists between IVT and cancer.
- IVT can serve as an early indicator of an undiagnosed malignancy.
- Extensive venous gangrene and advanced cancer portend a poor prognosis.
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